Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity.

نویسندگان

  • Monica Arenas
  • Gemma Simpson
  • Cathryn M Lewis
  • El-Monsor Shobowale-Bakre
  • Emilia Escuredo
  • Lynette D Fairbanks
  • John A Duley
  • Azhar Ansari
  • Jeremy D Sanderson
  • Anthony M Marinaki
چکیده

carbohydrate-deficient glycoprotein syndrome. Electrophoresis 1997;18: 1819–26. 12. Tagliaro F, Crivellente F, Manetto G, Puppi I, Deyl Z, Marigo M. Optimised determination of carbohydrate deficient transferrin isoforms (CDT) in serum by capillary zone electrophoresis. Electrophoresis 1998;19:3033–9. 13. Crivellente F, Fracasso G, Valentini R, Manetto G, Riviera AP, Tagliaro F. Improved method for carbohydrate-deficient transferrin determination in human serum by capillary zone electrophoresis. J Chromatogr B 2000;739: 81–93. 14. Giordano BC, Muza M, Trout A, Landers JP. Dynamically coated capillaries allow for capillary electrophoretic resolution of transferrin sialoforms via direct analysis of human serum. J Chromatogr B 2000;742:79–89. 15. Lanz C, Kuhn M, Bortolotti F, Tagliaro F, Thormann W. Evaluation and optimization of capillary zone electrophoresis with different dynamic capillary coatings for the determination of carbohydrate-deficient transferrin in human serum. J Chromatogr A 2002;979:43–57. 16. Fermo I, Germagnoli L, Soldarini A, Dorigatti F, Paroni R. Capillary zone electrophoresis for determination of carbohydrate-deficient transferrin in human serum. Electrophoresis 2004;25:469–75. 17. Legros FJ, Nuyens V, Minet E, Emonts P, Boudjeltia KZ, Courbe A, et al. Carbohydrate-deficient transferrin isoforms measured by capillary zone electrophoresis for detection of alcohol abuse. Clin Chem 2002;48:2177– 86. 18. Aldén A, Ohlson S, Påhlsson P, Rydén I. HPLC analysis of carbohydrate deficient transferrin isoforms isolated by the Axis-Shield %CDT method. Clin Chim Acta 2005;356:143–6. 19. Stout RL. Detecting alcohol abuse: the value of carbohydrate-deficient transferrin. J Insur Med 1998;30:123–4.

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Assessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia

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Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics.

Thiopurine S-methyltransferase (TPMT) plays an important role in the metabolism of thiopurine drugs. In humans, a common genetic polymorphism for TPMT is a major factor responsible for individual variation in the toxicity and therapeutic efficacy of these drugs. Dogs (Canis familiaris) are also treated with thiopurine drugs and, similar to humans, they display large individual variations in thi...

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Cat Red Blood Cell Thiopurine S-Methyltransferase: Companion Animal Pharmacogenetics

A common genetic polymorphism for thiopurine S-methyltransferase (TPMT) is a major factor responsible for individual variation in the toxicity and therapeutic efficacy of thiopurine drugs in humans. We set out to determine whether inheritance might also influence the level of TPMT activity in the domestic cat, Felis domesticus. As a first step, red blood cell (RBC) TPMT activity was measured in...

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عنوان ژورنال:
  • Clinical chemistry

دوره 51 12  شماره 

صفحات  -

تاریخ انتشار 2005